Activity Description

Patients who are immunocompromised or critically ill represent a particularly vulnerable population for infectious disease. One of the most common infections in immunosuppressed patients, including hematopoietic and solid organ transplant recipients, is cytomegalovirus (CMV). Infections caused by Gram-negative bacteria are also a significant concern in immunocompromised or critically ill patients. Management of both CMV and Gram-negative bacterial infections can be complicated by multidrug resistance, which limits treatment options and negatively impacts outcomes. New options for preventing and managing these serious infections have recently been introduced, and other agents are in late stages of clinical development.

This activity has been designed to help clinicians analyze and apply best practices in managing serious infections in immunocompromised and critically ill patients. The program consists of 3 modules, each with 4 clinically-relevant cases involving serious infections, including CMV and multidrug-resistant Gram-negative bacterial infections. This interactive online case-based format allows you to reflect on your own clinical decision making, and compare your decisions with those of an expert panel. Each module also provides the opportunity to review key risk factors for infections, issues that may impact therapeutic choices, and recently approved and investigational agents.

What if I only have 5-15 minutes in my busy day to learn?

Don’t worry, this program is designed to save your progress across multiple sessions, so you can start and stop at anytime. As long as you have internet access, you can log in with your phone or computer, whether you’re waiting in the grocery line, in between patients, or during lunch.

Why is the program divided into modules and cases?

To accommodate short bursts of learning and to address a variety of infections, this program offers 3 modules with 4 cases per module:

  • Module 1: Cytomegalovirus (CMV) prevention in transplant patients
  • Module 2: CMV treatment in transplant patients
  • Module 3: Gram-negative bacterial infections

Each case will take approximately 15 minutes to complete for a total of 1 hour per module.

You may choose to complete one or all modules; you do not have to complete all modules to be eligible for CME/CE credit.

How many CME/CE credits can I earn?

Each module is eligible for 1 hour of credit. CME/CE credits can be claimed for the number of modules that are completed successfully.

For each module, complete the pre-test, review the 4 cases, fill in the intra-activity questions and complete the post-test and evaluation to receive credit. Passing grade is 70% and there is no limit to the number of attempts. This activity is provided free of charge.

What is the educational approach?

This case-based activity helps you analyze and apply best practices in managing serious infections in immunocompromised and critically ill patients. The format allows you to reflect on your own reasoning process through a series of different clinical scenarios and compare your approach to that of a selected panel of experts within the transplant and bacterial infectious disease areas of expertise.

This format is modeled on the validated script concordance test, which, similar to a case study, simulates clinical situations in which physician must make decisions about diagnosis, treatment or management.

However, unlike a case study, the emphasis of the SCT exercise is not on establishing a single “right answer,” but in examining the multiple solutions and considerations required to make judgment calls in complex and uncertain situations.

For each case you will review a brief case presentation, with 3 clinical scenarios/questions.

Each scenario/question is presented in three parts:

  • “If you were thinking of…” – presents a clinical decision
  • “And then you find…” – presents new information (e.g., physical sign, pre-existing condition, imaging study or lab test result)
  • “The new information makes the clinical decision” (the question) – you vote on the impact the new information has on the clinical decision, using a five-point Likert scale
  • Once you have voted, you will be able to viewable
    • The expert panel scores and comments, i.e. how they voted and their rationale
    • The data slides

Three important points:

  • The three questions in each case are
    • Completely independent of each other
    • NOT sequential (the new information provided in each question does not carry over to the next)
  • The question you are being asked is NOT
    • Whether you agree with the proposed clinical decision
    • Or how important or useful you think the new information is
  • The question you are being asked is, how does the new information impact the clinical decision?

Who should participate?

This program is intended for specialists in infectious diseases, transplant, hematology/oncology, critical care, hospitalists and hospital pharmacists.

What are the learning objectives?

Upon completion of the overall program, you should be able to:

  1. List risk factors associated with CMV and multidrug-resistant (MDR) Gram-negative bacterial infections in immunosuppressed or critically ill patients
  2. Describe currently available and investigational therapeutic options for preventing and treating CMV infections
  3. Evaluate best practices for the antibiotic treatment of MDR Gram-negative bacterial infections in immunocompromised and critically ill patients.

Each module has specific learning objectives. Select a module to learn more.

Who developed the program?

This program was developed by our esteemed scientific committee:

Roy F. Chemaly, MD, MPH, FIDSA, FACP
Professor of Medicine
Director, Infection Control Section
Director of Clinical Virology
Department of ID/IC/EH
UT MD Anderson Cancer Center
Houston, TX
Committee Chairman

Keith Kaye, MD, MPH
Professor of Internal Medicine
Director of Clinical Research, Division of Infectious Diseases
University of Michigan Medical School
Ann Arbour, MI

Camille Kotton, MD, FIDSA, FAST
Clinical Director, Transplant and Immunocompromised Host Infectious Diseases
Infectious Diseases Division
Massachusetts General Hospital
Harvard Medical School
Boston, MA

Twelve expert panelists scored the cases and provided expert opinions. Please refer to the Faculty page for details about the Expert Panel and Planning Committee.

Accrediting Partners

This activity is jointly provided by Context Healthcare Group and the University of Cincinnati with ACPE accreditation provided by the University of South Carolina College Of Pharmacy.

University of Cincinnati

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the University of Cincinnati and Context Healthcare Group. The University of Cincinnati is accredited by the ACCME to provide continuing medical education for physicians.

The University of Cincinnati designates this enduring material activity for a maximum of 3 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

University of South Carolina College of Pharmacy

The University of South Carolina College of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. Each of the three modules in this program is accredited for 1.0 home study contact hours (0.1 CEUs) of application-based programming for pharmacists (ACPE 0062-9999-18-036-H01-P, 0062-9999-18-037-H01-P, 0062-9999-18-038-H01-P). To claim ACPE credit and have this credit submitted to the NABP CPE Monitor, the pharmacist-specific registration and evaluation must be completed per the instructions which will be provided at the completion of each home study. Release date: March 1, 2018. Expiration date: February 29, 2020.

About Context Healthcare Group

Context Healthcare Group creates engaging and impactful continuing medical education programs. We believe education should be interesting, innovative and inspiring – and that it should be provided within a context of rigorous science and creativity. Our mission is to deliver CME programs and tools that advance clinicians’ skills and knowledge, and improve disease management.



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Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not approved by the FDA, or FDA-approved agents that do not have an indication for the specific area being discussed. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s condition and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Copyright Notice

Copyright © 2019. This CME/CE-certified activity is held as copyrighted © by the University of Cincinnati and by Context Healthcare Group. Through this notice, the University of Cincinnati and Context Healthcare Group grant permission of its use for educational purposes only. Nothing contained herein shall be construed as conferring any other license or right under any University of Cincinnati or Context Healthcare Group copyright. These materials may not be used, in whole or in part, for any commercial purposes without prior permission in writing from the copyright owners.

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